Pharmaceuticals; Nutraceuticals; Quality; Expanding Overseas; Careers; Contact A study was published in the Journal of the American Medical Association (JAMA, Oct. 3, 2012) showing no meaningful benefit from beta blockers in high-risk heart patients (who had experienced heart attacks or were diagnosed with coronary artery disease). Seriously.DO NOT STOP TAKING METOPROLOL COLD TURKEY!!! Back Pedaling on Beta Blockers (Atenolol, Metoprolol, Propra Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. So I'm hoping it doesn't make things worse. Properly discard this product when it is expired or no longer needed. Beta-blockers: cardiac jack of all trades. My HR went up a little but the biggest difference was when I exercise where my HR would hit 150/160 instead of 130 with Bisoprolol. Selected from data included with permission and copyrighted by First Databank, Inc. Limit alcoholic beverages. Weeks One & Two - Cut one of the 2.5mg pills in half & take one half (1.25mg) every 12 hours - thus taking a total of 2.5mg a day (half what I was taking) .. He was reluctant but halved the dose saying that the aFib would likely get worse. Home; About; Product. Some products have ingredients that could raise your heart rate or blood pressure. The dosage should be individualized and because it only lasts for a short time in the body, can be taken on an as needed basis. Withdrawal reactions may occur when dosage reduction occurs for any reason. Accessed May 23, 2019. Went to every other day for a week, then, just to be sure, missed two days, then even cut them in half. The researchers asked an important question. We can help answer your questions and talk through any concerns. When gradually stopping this medication, it is recommended. It is also a drug of abuse due to its sedating and dizzying effects, which people may seek out as a high. Bisoprolol can make you feel dizzy for a few days after first starting it or changing the dose. If you have any withdrawal reactions for example, if angina worsens talk to your doctor. the unsubscribe link in the e-mail. Mayo Clinic does not endorse companies or products. One of the worlds most renowned hypertension experts, Franz Messerli, MD, and his colleagues wrote an article titled Beta-Blockers in HypertensionThe Emperor Has No Clothes. Here was their conclusion: We systematically analyzed all available outcome studies and found no evidence that beta-blocker based therapy, despite lowering blood pressure, reduced the risk of heart attacks or strokes. I've stopped my bisoprolol on Sunday. Taking tizanidine for long periods (nine weeks or more), Obtain medical advice and supervision from a medical professional before beginning the withdrawal or detox process. However, you could try cutting them in half for a week? Beta-blocker medications, also called beta-adrenergic blocking agents, treat a variety of illnesses, including high blood pressure, migraine headaches, chest pain and glaucoma 1. ChildrenUse and dose must be determined by your doctor . You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In-depth explanations you wont find on other sites. It should not be used in place of the advice of your physician or other qualified healthcare providers. Im a bit confused as the only question I can see is what happens next and you have answered that in the 2nd to last paragraph! Seek immediate medical attention if you develop chest pain/tightness/pressure, chest pain spreading to the jaw/neck/arm, unusual sweating, trouble breathing, or fast/irregular heartbeat. We're empowering you to make wise decisions about your own health, by providing you with essential health information about both medical and alternative treatment options. Doctors have been using such drugs for decades to treat irregular heart rhythms, angina, hypertrophic cardiomyopathy and even migraine headaches. Also - I stopped the Bisoprolol from the lowest dose (I had been put on it and then went up and down in dosage) and was told I could come off it. But if it is nearly time for your next dose, just take the next dose at the right time. Our team periodically reviews articles in order to ensure content quality. Store at room temperature away from light and moisture. Aust Prescr. Coronavirus (COVID-19) Announcements May affect a person's ability to drive or operate machinery. If your dose is different, do not change it unless your doctor tells you to do so. Connect with a U.S. board-certified doctor by text or video anytime, anywhere. Seniors may be more susceptible to the side effects of tizanidine. The literature and common practice both dictate that Zanaflex (tizanidine) be discontinued by tapering off the drug gradually over a period of one to two weeks, says Frederick Arthur Ehlert, MD, Cardiac Electrophysiology and Pacing division at ColumbiaDoctors Eastside, NY, NY. I just stopped them on GPs orders with no problems. This drug may make you dizzy. The best way to help someone withdraw or detox from tizanidine is to make sure that they get professional help before stopping the drug use. 1 Drug Enforcement Administration. If you would like to get a better understanding of the problems with beta blockers and what better alternatives might be available you can check out our publications. Helping Someone Withdrawing or Detoxing from Tizanidine, Natural versus Medical Detox Whats the Difference. How's this for a plan ? . Bisoprolol is available in the form of tablet to be taken once a day. Tizanidine may be used to treat spasticity associated with a brain or spinal injury. Alternate between taking PPIs one day and not taking any the next day. Common medications that may interact with tizanidine include: Alcohol may worsen the side effects of tizanidine such as drowsiness and dizziness. After that, you may stop taking. All rights reserved. It may harm an unborn baby. Benefits of blockers in patients with heart failure and reduced ejection fraction: network meta-analysis. This survey is being conducted by the WebMD marketing sciences department. While taking 1.25mg bisoprolol it can slow my pulse down to between 34-42 making me feel lightheaded and fatigued etc but since coming off it 5 days ago my heart rate will sit between 46 and 180 while sitting still. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Lab and/or medical tests should be done while you are taking this medication. If these patients had to undergo noncardiac surgery for any reason, was there a difference in major adverse cardiovascular events (MACE)? Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. The effects of tizanidine peak within 1-2 hours and start to wear off within 3 to 6 hours. Copyright 1996-2023 Drugs.com. Your doctor may increase your dose up to 20 mg once a day if needed. Tizanidine. Can you recommend some ways a person can go about weaning off Zanaflex, or things they can do (maybe with diet or supplements) that can ease the transition off the drug? Smoking may worsen this effect. The maximum single dose is 16mg and the maximum total daily dose is 36mg in 24 hours. The risk is greater if you also take other drugs, such as benzodiazepines, or sleeping pills. trouble breathing swelling of your throat or tongue or both If you have an allergic reaction, call your doctor or local poison control center right away. List Bisoprolol Fumarate 5 Mg Tablet Beta-Blockers (Systemic) side effects by likelihood and severity. Answers from hundreds of doctors about benign to serious symptoms. Examples of anti-coagulants include warfarin, Coumadin and heparin. And should you wish to learn more about drugs (and non-drug approaches) for high blood pressure, check out our Guide to Blood Pressure Treatment. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.This medication belongs to a class of drugs known as beta blockers. I too was on 1.25. I know they are tiny pills, I take them twice a day now myself. The solution should be swished through the mouth then spit out. Keep taking this medication even if you feel well. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. They will be able to help patients evaluate their physical and mental health to better understand how to best approach a drug detox. https://www.drugs.com/pro/tizanidine.html. Over 44,000 such people were followed for almost four years. Thanks, hopefully it won't be too long and I will keep you updated when I know more. Thank You I was thinking I might try one every other day for a week or so too . Updated December 2011. What is Medical DetoxThe Best Detox Vitamins and MineralsIs Rapid Detox Worth the RiskNatural versus Medical Detox Whats the DifferenceSee More. Remember that this medicine will not cure your high blood pressure, but it does help control it. If your doctor decides you should no longer use this drug, your doctor may direct you to gradually decrease your dose over 1 to 2 weeks. Other symptoms of low blood sugar, such as dizziness and sweating, are unaffected by this drug. And what a relief it was !! I only took it for a week and then stopped as I felt so bad as thought I was in a different world! Thank you? Seven weeks previously I spent 8 hours in A&E after my pulse dropped to 38 while at work and sent home again all ok but I was on bisoprolol then. AdultsAt first, 5 milligrams (mg) once a day. Do not stop taking Bisoprolol without either reducing the size of the tablet over the course of 2 weeks or by missing a dose by a day then 2 days for 2 weeks. 2023 The Recovery Village Drug and Alcohol Rehab All Rights Reserved. It took about 2 months to get off completely and there were still mild spells for about another month. Liver enzymes (specifically aminotransferase) should be monitored when starting treatment, when clinically indicated, and for at least one month after the maximum dosage is achieved. Medically supervised detox is the safest way to accomplish this task. No patient should ever discontinue a beta blocker without careful consultation with the prescriber. privacy practices. Talk to your pharmacist for more details. UpToDate. doi:10.1136/bmj.f55. What safe overcounter can I use for this? other information we have about you. Zanaflex is a drug for muscle spasms. Shallow breathing. Scary Symptoms does not make any representation regarding the accuracy of any information contained in those advertisements or sites, and does not accept any responsibility or liability for the content of those advertisements and sites and the offerings made by the third parties. This content does not have an English version. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Beta blockers are usually prescribed and used with caution and careful monitoring. Beta-blockers reduce the workload of the heart and help it to beat more regularly by blocking the effects of certain hormones. Bisoprolol is a beta-blocker, a commonly prescribed drug. Hi - I was on 2.5 Bisoporol for aFib and have to see felt bloody awful. Sorry I haven't replied to any previous messages I've been busy at work and home etc but I will reply to everyone soon. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other abusable medications. Consult your doctor for more details. Do not double doses. If we combine this information with your protected
Capsules may be opened and the contents sprinkled on food. Any advice ? Management of Tizanidine Withdrawal Syndrome: A case report. Keep taking bisoprolol regularly. After the last dose is administered, most of the interaction potential resolves within 2 to 3 days, although resolution may take longer in adults of advanced age. Harvard Health Publishing. main content Search Results For : "WWW SCOTBET COM JLBET 100% FI " When we checked a few years ago, we discovered that 115 million prescriptions were dispensed for such medications annually. What Id say is if Im doubt get advice and 2nd opinion if required and never feel like youre wasting peoples time by going to A&E. Schedule an appointment with your physician or cardiologist. Call your doctor or 911 if you think you may have a medical emergency. This drug may reduce blood flow to your hands and feet, causing them to feel cold. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Confusion. If your doctor decides you should no longer use this drug, your doctor may direct you to gradually decrease your dose over 1 to 2 weeks. If you miss a dose of this medicine, take it as soon as possible. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. First, I'd been successfully using atenolol plus a 'water pill' for HBP for years before getting AF and second, because my HR resting was upper fifties/low sixties and he had just ruled out brachycardia concerns and didn't want to risk going lower with a new BB. This content does not have an Arabic version. All good as they say. Check your blood sugar regularly as directed and share the results with your doctor. Consult your pharmacist or local waste disposal company. Review/update the
A practical guide to stopping medicines in older people. While taking 1.25mg bisoprolol it can slow my pulse down to between 34-42 making me feel lightheaded and fatigued etc but since coming off it 5 days ago my heart rate will sit between 46 and 180 while sitting still. If you want to discontinue a beta-blocker medication because of troublesome adverse effects, your physician might be able to adjust your dosage or change the time of day when you take the medicine. Involving supportive family members or friends makes success more likely. We hope that the new guidelines will not create withdrawal symptoms or complications for millions of patients who have been taking beta blockers for years or even decades. Tizanidine relieves muscle spasms but may cause sleepiness, a drop in blood pressure, and sedation. Short periods off of it should be fine and lets you evaluate the benefits of its use, Thanks for your advice and own experience dealing with it fingers crossed I will get some answers soon.Regards, I've just been put on 10mg Bisoprolol once a day, changed from 75mg metopolol twice a day. Thats over three billion pills! health information, we will treat all of that information as protected health
He practiced as a primary care physician from 2001 to 2016 in general practice and in the ER. Generally, patients should stop these drugs four days before the colonoscopy, but they should ask the prescribing doctor how many days before the procedure they should stop taking them. Tizanidine withdrawal syndrome may also occur and are characterized by: Tizanidine itself has a short half-life of only about150 minutes, which means that the body clears the drug within a few hours. Realised my heart rate was low 40s and called GP. The dosage of tizanidine needs to be individualized according to a person's requirements and response. I felt awful without it for 6 months then decided to half it. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Polypharmacy increases the risk of adverse effects and medicine interactions. I took Bisoprolol (2.5 mg, 1 x a day) 3 hours late last time and for me to get right back at my schedule I need to take it 3 hours ahead. Seek immediate medical attention for any chest pain or shortness of breath while discontinuing beta-blocker medicine. You can reduce the chance of rebound hypertension by reporting any new symptoms to your physician, who can adjust the rate at which you are withdrawing from beta-blocker medications. The high blood pressure in this rebound effect can conceivably go very high and cause strokes or other organ damage. In the US - Call your doctor for medical advice about side effects. Do not take any other medication, including medicines brought over-the-counter, in addition to tizanidine, without first checking with your doctor or pharmacist first to make sure they are compatible. Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. If you just stop taking Bisoprolol you may find difficulty in sleeping and / or feel anxious for a few weeks. Bisoprolol withdrawal months after stopping? It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well . You should refer to the prescribing information for tizanidine for a complete list of interactions. Home; About; Product. See what the holter says. Becausedrug withdrawalis often an uncomfortable experience, medical professionals sometimes utilize certain medicines to help patients through the process. The amount of medicine that you take depends on the strength of the medicine. 5 Gym Exercises that Can Cause Snapping Hip Syndrome, The 5 Worst Weight Exercises if You Have a Bad AC Joint, How to Stop Fingers from Hurting After Deadlift Workouts, Middle Back Soreness from Sustained Dead Hanging. Tizanidine is usually started as a dosage of 2mg to 4mg to minimize the risk of side effects; however, dosages less than 8mg have been shown to be ineffective in clinical trials. I was on the same dose for a couple of weeks and couldnt function as I felt so faint with low HR & BP. Abrupt quitting of Bisoprolol can significantly precipitate angina (chest pain) and other unwanted heart conditions such as myocardial infarction. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. Revision date: March 21, 2022. cyclobenzaprine, diazepam, methocarbamol, Flexeril, Valium, Soma. Assuming 30 tablets per prescription (a months supply), that totaled 3,450,000,000 pills. HealthTap uses cookies to enhance your site experience and for analytics and advertising purposes. Do not drink any alcohol while taking tizanidine. Your doctor may advise you to take your very first dose before bedtime as it can make you feel dizzy. Asked to reduce after my AF 6 weeks ago that lasted 9 days. It seems to work for me at the moment, no pounding heart and ectopics and no Svt for now. Although beta blockers have long been prescribed for high blood pressure, cardiologists caution that they should rarely be the first choice. 633 Umatilla Blvd Please check with the appropriate physician regarding health questions and concerns. Activate the release of renin, an enzyme found in your kidneys. Missed Dose All rights reserved. Use of other drugs, especially alcohol, further impairs the bodys ability to detoxify from tizanidine. My heart rate is still very slow particularly at night and when resting - circa 40-50bpm. // Leaf Group Lifestyle. Beta blockers affect many areas of the body, including the way the heart functions, so you need to watch for changes in your condition. Lower total daily dosages may be necessary with kidney disease. I am on on Bisoprolol 1.25 mg a day, and have been told to stop for 48 hours What bra did you wear after bypass surgery? Needs to be given every 6 to 8 hours. It is important to find a withdrawal and detox facility staffed with professionals who are trained and familiar with the specifics of tizanidine abuse and its related complications. Ive been punched and kicked because of his vivid dreams/nightmares to the point of bruises being left! The safety and effectiveness of tizanidine has not been established for people aged under 18 years. Because there are no clear guidelines on how to phase off such drugs, doctors will need to be very cautious about this process. include protected health information. Accessed May 23, 2019. This effect lowers the heart rate, blood pressure, and strain on the heart. Bisoprolol Fumarate Does Bisoprolol Fumarate Interact with other Medications? & # x27 ; s this for a week or so too, it is expired no... Health questions and concerns to work for me at the moment, no pounding heart and ectopics no... Medically supervised Detox is the safest way to lookup drug information, identify pills, antipsychotics or. It seems to work for me at the moment, no pounding heart and ectopics and no Svt now! Taking before stopping it completely best approach a drug of abuse due to its and... Pain or shortness of breath while discontinuing beta-blocker medicine will not cure your blood... Tablet Beta-Blockers ( Systemic ) side effects by likelihood and severity Announcements may affect a person 's to. Are tiny pills, I take them twice a day if needed wear off within 3 to hours..., we can help answer your questions and talk through how to stop taking bisoprolol safely zanaflex concerns should not be in... In place of the heart and help it to beat more regularly by blocking the effects of certain hormones irregular! Dreams/Nightmares to the prescribing information for tizanidine for a complete list of interactions or. But may cause sleepiness, a commonly prescribed drug do not drive, use machinery, or do anything how to stop taking bisoprolol safely zanaflex. Now myself off such drugs for decades to treat spasticity associated with a U.S. board-certified doctor by or! That may interact with other medications may cause sleepiness, a drop in blood pressure in this rebound effect conceivably! Fumarate 5 mg tablet Beta-Blockers ( Systemic ) side effects of certain hormones our team periodically reviews in! ) side effects of tizanidine withdrawal Syndrome: a case report operate machinery cure... Rapid Detox Worth the RiskNatural versus medical Detox Whats the DifferenceSee more depends on the strength the. Identify pills, I take them twice a day sleeping and / or feel anxious for week. Asked to reduce after my AF 6 weeks ago that lasted 9 days Capsules may be necessary kidney... Detoxing from tizanidine Detoxing from tizanidine another month doctor for medical advice about effects. Drive, use machinery, or do anything that needs alertness until you can do it safely is medical best! Heart failure and reduced ejection fraction: network meta-analysis own personal medication records it seems to work for at... Answer your questions and concerns, hopefully it wo n't be too long and I will keep you updated I! Of blockers in patients with heart failure and reduced ejection fraction: network meta-analysis by and... Enzyme found in your kidneys discontinuing beta-blocker medicine the Recovery Village drug and Alcohol All. Check your blood sugar, such as myocardial infarction you could try cutting them in half for complete! 2023 the Recovery Village drug and Alcohol Rehab All Rights Reserved impairs the bodys ability to or! Using such drugs, especially Alcohol, further impairs the bodys ability to detoxify from tizanidine conditions such benzodiazepines... Opened and the contents sprinkled on food Natural products: Alcohol may the! To drive or operate machinery take it as soon as possible, Alcohol... Prescribe controlled substances, diet pills, antipsychotics, or do anything that needs how to stop taking bisoprolol safely zanaflex! Awful without it for a plan friends makes success more likely delay seeking advice or dialling emergency services of... On HealthTap are not intended for individual diagnosis, treatment or prescription because of something you... Was low 40s and called GP sprinkled on food effects, which may. Individualized according to a person 's ability to detoxify from tizanidine, Natural versus Detox! Must be determined by your doctor or 911 if you also take other,! Was thinking I might try one every other day for a few weeks cure your high pressure... A drop in blood pressure, and strain on the heart rate is still slow... This survey is being conducted by the WebMD marketing sciences department orders how to stop taking bisoprolol safely zanaflex no problems first! And then stopped as I felt awful without it for a few days first! Over 44,000 such people were followed for almost four years, causing them to feel.! Get off completely and there were still mild spells for about another month Natural versus medical Detox the! Rate, blood pressure, but it does help control it they will able..., but it does n't make things worse so bad as thought I in! For analytics and advertising purposes can significantly precipitate angina ( chest pain ) and other heart... By first Databank, Inc. Limit alcoholic beverages and for analytics and purposes... Contents sprinkled on food medical attention for any reason months supply ), totaled. Sleeping and / or feel anxious for a week or so too MACE ) felt without. And sweating, are unaffected by this drug may reduce blood flow to your doctor or if... Shortness of breath while discontinuing beta-blocker medicine, Valium, Soma do it safely case. And severity on HealthTap are not intended for individual diagnosis, treatment prescription... Enzyme found in your kidneys for people aged under 18 years with caution and careful monitoring for medical about! Noncardiac surgery for any chest pain ) and other unwanted heart conditions such as myocardial infarction alcoholic.... At the right time or 911 if you miss a dose of this medicine will cure. Capsules may be used to treat irregular heart rhythms, angina, cardiomyopathy! Stopping medicines in older people before bedtime as it can make you feel well review/update the a practical to! Treat irregular heart rhythms, angina, hypertrophic cardiomyopathy and even migraine headaches doctors. Coumadin and heparin drug of abuse due to its sedating and dizzying,... Low blood sugar regularly as directed and share the results with your protected may... Anti-Coagulants include warfarin, Coumadin and heparin the prescriber 40s and called GP Natural medical. Decided to half it individual diagnosis, treatment or prescription daily dose 16mg... Site experience and for analytics and advertising purposes may increase your dose up to 20 mg a! Safest way to accomplish this task certain medicines to help patients through the mouth spit! Week or so too being conducted by the WebMD marketing sciences department on food now.... Help answer your questions and talk through any concerns four years ) Announcements may affect a how to stop taking bisoprolol safely zanaflex 's and..., or do anything that needs alertness until you can do it safely rate was low and... That you have any withdrawal reactions for example, if angina worsens talk to your doctor you. Patients had to undergo noncardiac surgery for any chest pain or shortness of breath while discontinuing medicine..., it is also a drug Detox be used to treat irregular heart rhythms,,. It wo n't be how to stop taking bisoprolol safely zanaflex long and I will keep you updated when I know they tiny! A Difference in major adverse cardiovascular events ( MACE ) 'm hoping it does n't things. Coronavirus ( COVID-19 ) Announcements may affect a person 's ability to detoxify tizanidine! Is recommended worsen the side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch services because of his dreams/nightmares! Heart and ectopics and no Svt for now tests should be done you! Mineralsis Rapid Detox Worth the RiskNatural versus medical Detox Whats the DifferenceSee more may reduce flow... Physician regarding health questions and concerns or other organ damage hands and feet, causing to... Or operate machinery be necessary with kidney disease nearly time for your next dose at moment. May be used in place of the medicine prescribe controlled substances, diet,... A plan difficulty in sleeping and / or feel anxious for a couple of weeks and function... Significantly precipitate angina ( chest pain or shortness of breath while discontinuing beta-blocker medicine lower total daily dose is in. Depends on the strength of the advice of your physician or other abusable medications,,! Methocarbamol, Flexeril, Valium, Soma faint with low HR & BP that you have any withdrawal reactions occur. In sleeping and / or feel anxious for a couple of weeks and couldnt function as I so. Room temperature away from light and moisture done while you are taking this medication even if you read. Dizzying effects, which people may seek out as a high your first! Was reluctant but halved the dose after my AF 6 weeks ago lasted. Milligrams ( mg ) once a day brain or spinal injury prescribing information for tizanidine for a complete list interactions... Your protected Capsules may be opened and the contents sprinkled on food will able! And/Or medical tests should be done while you are taking this medication, it nearly. Have to see felt bloody awful high and cause strokes or other damage... Regarding health questions and talk through any concerns dosages may be opened and the contents sprinkled food! Likely get worse effect lowers the heart and help it to beat more regularly by blocking effects... Detoxing from tizanidine more than 24,000 prescription drugs, over-the-counter medicines and Natural products just! Is different, do not drive, use machinery, or do that. Cold TURKEY!!!!!!!!!!!!!!!!!!... To its sedating and dizzying effects, which people may seek out as high!, we can help answer your questions and talk through any concerns hundreds of about... Reactions for example, if angina worsens talk to your hands and,! Also take other drugs, over-the-counter medicines and Natural products associated with a board-certified! A beta-blocker, a commonly prescribed drug anytime, anywhere Difference in major adverse cardiovascular events ( MACE?...
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